Assay Detail
Functional
CHEMBL5506872
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Cytotoxicity against human LoVo cells assessed as reduction in cell viability incubated for 5 days by CellTiter-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.15 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647810 | ELIMUSERTIB | 1.0 | 1 | 7.57 |
| CHEMBL5095260 | CAMONSERTIB | 2.0 | 1 | 7.55 |
| CHEMBL4650286 | M4344 | 1.0 | 1 | 7.07 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647810 | ELIMUSERTIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5095260 | CAMONSERTIB | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4650286 | M4344 | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 377.0 | nM | 6.42 |