Assay Detail
Binding
CHEMBL5507157
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Inhibition of LCK (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.75 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558185 | — | — | 1 | 7.92 |
| CHEMBL5555917 | — | — | 1 | 7.88 |
| CHEMBL5555659 | — | — | 1 | 7.73 |
| CHEMBL5555788 | — | — | 1 | 7.66 |
| CHEMBL5558967 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558185 | — | IC50 | = | 11.97 | nM | 7.92 |
| CHEMBL5555917 | — | IC50 | = | 13.24 | nM | 7.88 |
| CHEMBL5555659 | — | IC50 | = | 18.45 | nM | 7.73 |
| CHEMBL5555788 | — | IC50 | = | 21.94 | nM | 7.66 |
| CHEMBL5558967 | — | IC50 | = | 28.0 | nM | 7.55 |