Assay Detail
Binding
CHEMBL5507225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2 in mouse Ba/F3-TEL-JAK2 cells assessed as inhibition of JAK1-driven cell growth incubated for 72 hrs by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Ba/F3-TEL-JAK2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of C-5 substituted pyrrolopyridine derivatives as potent Janus Kinase 1 inhibitors with excellent selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.42 |
| CHEMBL5542400 | — | — | 1 | 5.51 |
| CHEMBL5563563 | — | — | 1 | 5.19 |
| CHEMBL5566342 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL5542400 | — | IC50 | = | 3067.0 | nM | 5.51 |
| CHEMBL5563563 | — | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL5566342 | — | IC50 | = | 7827.0 | nM | 5.11 |