Assay Detail
Functional
CHEMBL5507329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human 22Rv1 cells incubated for 72 hrs by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.78 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561463 | — | — | 1 | 5.70 |
| CHEMBL5559881 | — | — | 1 | 5.63 |
| CHEMBL5558400 | — | — | 1 | 5.62 |
| CHEMBL5555217 | — | — | 1 | 5.09 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 5.04 |
| CHEMBL5561484 | — | — | 1 | 4.93 |
| CHEMBL5557454 | — | — | 1 | 4.78 |
| CHEMBL5532410 | — | — | 1 | 4.71 |
| CHEMBL5557319 | — | — | 1 | 4.65 |
| CHEMBL4238437 | — | — | 1 | 4.57 |
| CHEMBL5557212 | — | — | 1 | 4.56 |
| CHEMBL5562651 | — | — | 1 | 4.50 |
| CHEMBL5559780 | — | — | 1 | 4.43 |
| CHEMBL5517678 | — | — | 1 | 4.39 |
| CHEMBL5556734 | — | — | 1 | 4.25 |
| CHEMBL5560443 | — | — | 1 | 4.24 |
| CHEMBL5566714 | — | — | 1 | 4.24 |
| CHEMBL4513510 | ASP-9521 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561463 | — | IC50 | = | 2013.0 | nM | 5.70 |
| CHEMBL5559881 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL5558400 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL5555217 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 9090.0 | nM | 5.04 |
| CHEMBL5561484 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL5557454 | — | IC50 | = | 16430.0 | nM | 4.78 |
| CHEMBL5532410 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL5557319 | — | IC50 | = | 22430.0 | nM | 4.65 |
| CHEMBL4238437 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL5557212 | — | IC50 | = | 27330.0 | nM | 4.56 |
| CHEMBL5562651 | — | IC50 | = | 31980.0 | nM | 4.50 |
| CHEMBL5559780 | — | IC50 | = | 37040.0 | nM | 4.43 |
| CHEMBL5517678 | — | IC50 | = | 40960.0 | nM | 4.39 |
| CHEMBL5556734 | — | IC50 | = | 56710.0 | nM | 4.25 |
| CHEMBL5560443 | — | IC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL5566714 | — | IC50 | = | 58270.0 | nM | 4.24 |
| CHEMBL4513510 | ASP-9521 | IC50 | > | 50000.0 | nM | - |