Assay Detail
Binding
CHEMBL5507502
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Binding affinity to menin (unknown origin) incubated for 1 hr by fluorescence polarization assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pyrrolo[2,3-d]pyrimidines as potent menin-mixed lineage leukemia interaction inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.18 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5565919 | — | — | 1 | 6.60 |
| CHEMBL5527907 | — | — | 1 | 6.42 |
| CHEMBL5555656 | — | — | 1 | 6.35 |
| CHEMBL5557085 | — | — | 1 | 6.33 |
| CHEMBL5557705 | — | — | 1 | 6.28 |
| CHEMBL3586089 | — | — | 1 | 6.22 |
| CHEMBL5518084 | — | — | 1 | 6.14 |
| CHEMBL5560342 | — | — | 1 | 5.98 |
| CHEMBL5562800 | — | — | 1 | 5.94 |
| CHEMBL5559575 | — | — | 1 | 5.91 |
| CHEMBL5558500 | — | — | 1 | 5.83 |
| CHEMBL5557241 | — | — | 1 | - |
| CHEMBL5560540 | — | — | 1 | - |
| CHEMBL5532611 | — | — | 1 | - |
| CHEMBL5566849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5565919 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5527907 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5555656 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5557085 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5557705 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3586089 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5518084 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5560342 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL5562800 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5559575 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5558500 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5557241 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5560540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5532611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5566849 | — | IC50 | > | 10000.0 | nM | - |