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Assay Detail

CHEMBL5507503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of novel pyrrolo[2,3-d]pyrimidines as potent menin-mixed lineage leukemia interaction inhibitors.
Bai H, Yang Z, Lei H, Wu Y, Liu J, Yuan B, Ma M, Gao L, Zhang SQ, Xin M.
Eur J Med Chem (2024) 268 : 116226 -116226
PubMed 38367493 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.64 5.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5527907 1 5.97
CHEMBL5557085 1 5.90
CHEMBL5555656 1 5.89
CHEMBL5562800 1 5.87
CHEMBL5557705 1 5.77
CHEMBL5560342 1 5.71
CHEMBL5565919 1 5.70
CHEMBL5518084 1 5.69
CHEMBL5558500 1 5.28
CHEMBL5557241 1 5.18
CHEMBL3586089 1 5.04
CHEMBL5560540 1 -
CHEMBL5532611 1 -
CHEMBL5566849 1 -
CHEMBL5559575 1 -
CHEMBL2216870 IDELALISIB 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5527907 IC50 = 1070.0 nM 5.97
CHEMBL5557085 IC50 = 1260.0 nM 5.90
CHEMBL5555656 IC50 = 1290.0 nM 5.89
CHEMBL5562800 IC50 = 1350.0 nM 5.87
CHEMBL5557705 IC50 = 1690.0 nM 5.77
CHEMBL5560342 IC50 = 1940.0 nM 5.71
CHEMBL5565919 IC50 = 2000.0 nM 5.70
CHEMBL5518084 IC50 = 2050.0 nM 5.69
CHEMBL5558500 IC50 = 5200.0 nM 5.28
CHEMBL5557241 IC50 = 6540.0 nM 5.18
CHEMBL3586089 IC50 = 9200.0 nM 5.04
CHEMBL5560540 IC50 > 10000.0 nM -
CHEMBL5532611 IC50 > 10000.0 nM -
CHEMBL5566849 IC50 > 10000.0 nM -
CHEMBL5559575 IC50 > 10000.0 nM -
CHEMBL2216870 IDELALISIB IC50 > 10000.0 nM -