Assay Detail
Binding
CHEMBL5507539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human menin-MLL protein-protein interaction by fluorescence polarization assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Menin/Histone-lysine N-methyltransferase MLL (CHEMBL2093861) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of novel pyrrolo[2,3-d]pyrimidines as potent menin-mixed lineage leukemia interaction inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.85 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586090 | — | — | 1 | 7.34 |
| CHEMBL3586089 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586090 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3586089 | — | IC50 | = | 446.0 | nM | 6.35 |