Assay Detail
Functional
CHEMBL5508601
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Antiviral activity against SARS-CoV-2 Omicron BA.1 harboring NSP5 L50F/E166A/L167F mutant infected in HEK293T cells measured after 48 hrs by Nano-Glo luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.63 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 8.05 |
| CHEMBL5532059 | — | — | 1 | 6.31 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5532059 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 2900.0 | nM | 5.54 |