Assay Detail
Binding
CHEMBL5508616
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Inhibition of human FGFR3 (450 to 758 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 30 mins by ADP-Glo reagent based plate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558986 | — | — | 1 | 6.70 |
| CHEMBL5565446 | — | — | 1 | 6.33 |
| CHEMBL5560176 | — | — | 1 | 6.01 |
| CHEMBL5559706 | — | — | 1 | - |
| CHEMBL5556135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558986 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL5565446 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL5560176 | — | IC50 | = | 977.0 | nM | 6.01 |
| CHEMBL5559706 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5556135 | — | IC50 | > | 5000.0 | nM | - |