Assay Detail
Functional
CHEMBL5508747
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.89 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5523555 | — | — | 1 | 5.47 |
| CHEMBL5562196 | — | — | 1 | 5.28 |
| CHEMBL5523445 | — | — | 1 | 5.26 |
| CHEMBL5562765 | — | — | 1 | 5.23 |
| CHEMBL5557100 | — | — | 1 | 5.21 |
| CHEMBL5561761 | — | — | 1 | 5.16 |
| CHEMBL5565871 | — | — | 1 | 5.14 |
| CHEMBL5542690 | — | — | 1 | 5.14 |
| CHEMBL5560773 | — | — | 1 | 5.04 |
| CHEMBL5560776 | — | — | 1 | 5.04 |
| CHEMBL3392741 | — | — | 1 | 5.03 |
| CHEMBL5532378 | — | — | 1 | 4.88 |
| CHEMBL5557814 | — | — | 1 | 4.81 |
| CHEMBL5559526 | — | — | 1 | 4.79 |
| CHEMBL5562321 | — | — | 1 | 4.76 |
| CHEMBL5562787 | — | — | 1 | 4.70 |
| CHEMBL5559268 | — | — | 1 | 4.66 |
| CHEMBL5523454 | — | — | 1 | 4.65 |
| CHEMBL5568379 | — | — | 1 | 4.60 |
| CHEMBL5562286 | — | — | 1 | 4.57 |
| CHEMBL5558678 | — | — | 1 | 4.57 |
| CHEMBL5566850 | — | — | 1 | 4.54 |
| CHEMBL5523517 | — | — | 1 | 4.49 |
| CHEMBL5560170 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5523555 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5562196 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5523445 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5562765 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5557100 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5561761 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5565871 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5542690 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5560773 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5560776 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3392741 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5532378 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL5557814 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5559526 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL5562321 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5562787 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5559268 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL5523454 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL5568379 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL5562286 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL5558678 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL5566850 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL5523517 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL5560170 | — | IC50 | = | 46200.0 | nM | 4.33 |