Assay Detail
Toxicity
CHEMBL5508767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.77 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3392741 | — | — | 1 | 4.84 |
| CHEMBL5523555 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3392741 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5523555 | — | IC50 | = | 20400.0 | nM | 4.69 |