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Assay Detail

CHEMBL5508987

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PRMT1 (unknown origin) by AlphaLISA assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protein arginine N-methyltransferase 1 (CHEMBL5524)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-based discovery of potent CARM1 inhibitors for colorectal cancer therapy.
Liu C, Li Y, Liu Z, Cao C, Lin M, Chen X, Yuan M, Fan Y, Gu X, Wang L, Yang F, Ye F, Jin J.
Eur J Med Chem (2024) 269 : 116288 -116288
PubMed 38460270 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.61 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5559689 1 8.49
CHEMBL5517922 1 8.40
CHEMBL5527874 1 8.40
CHEMBL5565736 1 8.30
CHEMBL5532462 1 8.05
CHEMBL5542306 1 8.05
CHEMBL5560201 1 7.85
CHEMBL5557453 1 7.82
CHEMBL5558900 1 7.80
CHEMBL5561358 1 7.80
CHEMBL5557488 1 7.57
CHEMBL5556985 1 7.48
CHEMBL5568475 1 7.38
CHEMBL5556070 1 7.38
CHEMBL5561789 1 7.28
CHEMBL5558087 1 7.25
CHEMBL5562404 1 7.25
CHEMBL5566868 1 6.80
CHEMBL5561536 1 6.55
CHEMBL418052 S-ADENOSYLHOMOCYSTEINE 1 6.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5559689 IC50 = 3.2 nM 8.49
CHEMBL5517922 IC50 = 4.0 nM 8.40
CHEMBL5527874 IC50 = 4.0 nM 8.40
CHEMBL5565736 IC50 = 5.0 nM 8.30
CHEMBL5532462 IC50 = 9.0 nM 8.05
CHEMBL5542306 IC50 = 9.0 nM 8.05
CHEMBL5560201 IC50 = 14.0 nM 7.85
CHEMBL5557453 IC50 = 15.0 nM 7.82
CHEMBL5558900 IC50 = 16.0 nM 7.80
CHEMBL5561358 IC50 = 16.0 nM 7.80
CHEMBL5557488 IC50 = 27.0 nM 7.57
CHEMBL5556985 IC50 = 33.0 nM 7.48
CHEMBL5568475 IC50 = 42.0 nM 7.38
CHEMBL5556070 IC50 = 42.0 nM 7.38
CHEMBL5561789 IC50 = 53.0 nM 7.28
CHEMBL5558087 IC50 = 56.0 nM 7.25
CHEMBL5562404 IC50 = 56.0 nM 7.25
CHEMBL5566868 IC50 = 157.0 nM 6.80
CHEMBL5561536 IC50 = 281.0 nM 6.55
CHEMBL418052 S-ADENOSYLHOMOCYSTEINE IC50 = 618.0 nM 6.21