Assay Detail
Binding
CHEMBL5509225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal GST-tagged human Mcl-1 expressed in Escherichia coli assessed as inhibition constant by TR-FRET analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 9.77 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297482 | AZD-5991 | 1.0 | 1 | 9.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297482 | AZD-5991 | Ki | = | 0.17 | nM | 9.77 |