Assay Detail
Binding
CHEMBL5509249
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Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.99 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650225 | MURIZATOCLAX | 1.0 | 1 | 10.82 |
| CHEMBL5542691 | — | — | 1 | 10.30 |
| CHEMBL4446369 | — | — | 1 | 10.21 |
| CHEMBL5542775 | — | — | 1 | 10.12 |
| CHEMBL4439276 | — | — | 1 | 8.92 |
| CHEMBL4472351 | — | — | 1 | 7.72 |
| CHEMBL3781822 | — | — | 1 | 7.51 |
| CHEMBL1331211 | — | — | 1 | 6.31 |
| CHEMBL5555963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650225 | MURIZATOCLAX | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL5542691 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL4446369 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL5542775 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL4439276 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4472351 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3781822 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1331211 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL5555963 | — | Ki | < | 0.01 | nM | - |