Assay Detail
Functional
CHEMBL5509271
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Antiproliferative activity against human LoVo cells measured after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.74 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5559889 | — | — | 1 | 4.87 |
| CHEMBL5558153 | — | — | 1 | 4.82 |
| CHEMBL5563598 | — | — | 1 | 4.81 |
| CHEMBL5542132 | — | — | 1 | 4.45 |
| CHEMBL5517891 | — | — | 1 | - |
| CHEMBL5566700 | — | — | 1 | - |
| CHEMBL5562203 | — | — | 1 | - |
| CHEMBL5563400 | — | — | 1 | - |
| CHEMBL5523646 | — | — | 1 | - |
| CHEMBL5560285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5559889 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL5558153 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5563598 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5542132 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL5517891 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5566700 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5562203 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5563400 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5523646 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5560285 | — | IC50 | > | 40000.0 | nM | - |