Assay Detail
Functional
CHEMBL5509272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.57 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558153 | — | — | 1 | 4.66 |
| CHEMBL5562203 | — | — | 1 | 4.63 |
| CHEMBL5559889 | — | — | 1 | 4.63 |
| CHEMBL5563598 | — | — | 1 | 4.53 |
| CHEMBL5560285 | — | — | 1 | 4.49 |
| CHEMBL5563400 | — | — | 1 | 4.46 |
| CHEMBL5517891 | — | — | 1 | - |
| CHEMBL5566700 | — | — | 1 | - |
| CHEMBL5523646 | — | — | 1 | - |
| CHEMBL5542132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558153 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL5562203 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL5559889 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL5563598 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL5560285 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL5563400 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL5517891 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5566700 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5523646 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5542132 | — | IC50 | > | 40000.0 | nM | - |