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Assay Detail

CHEMBL5509276

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Antiproliferative activity against human HFF-1 cells measured after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type HFF-1
Confidence 1 — Organism
Curated By Autocuration

Target

HFF-1 (CHEMBL4296427)
Type CELL-LINE
Organism Homo sapiens

Publication

Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.
Zheng BX, Long W, Zheng W, Zeng Y, Guo XC, Chan KH, She MT, Leung AS, Lu YJ, Wong WL.
J Med Chem (2024) 67 : 6292 -6312
PubMed 38624086 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.53 4.64
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5563598 1 4.64
CHEMBL5517891 1 4.55
CHEMBL5558153 1 4.51
CHEMBL5559889 1 4.49
CHEMBL5523646 1 4.46
CHEMBL5566700 1 -
CHEMBL5562203 1 -
CHEMBL5563400 1 -
CHEMBL5560285 1 -
CHEMBL5542132 1 -
CHEMBL5560752 1 -
CHEMBL5523493 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5563598 IC50 = 22700.0 nM 4.64
CHEMBL5517891 IC50 = 28300.0 nM 4.55
CHEMBL5558153 IC50 = 31100.0 nM 4.51
CHEMBL5559889 IC50 = 32700.0 nM 4.49
CHEMBL5523646 IC50 = 34700.0 nM 4.46
CHEMBL5566700 IC50 > 40000.0 nM -
CHEMBL5562203 IC50 > 40000.0 nM -
CHEMBL5563400 IC50 > 40000.0 nM -
CHEMBL5560285 IC50 > 40000.0 nM -
CHEMBL5542132 IC50 > 40000.0 nM -
CHEMBL5560752 Activity - -
CHEMBL5523493 Activity - -