Assay Detail
Binding
CHEMBL5509540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LMP2 using Ac-PAL-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 min by fluorescence based SpectraMax M5e plate reader
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.86 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870740 | — | — | 1 | 7.18 |
| CHEMBL4867229 | — | — | 1 | 7.16 |
| CHEMBL4877277 | — | — | 1 | 6.74 |
| CHEMBL4869559 | — | — | 1 | 6.62 |
| CHEMBL4866610 | — | — | 1 | 6.58 |
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870740 | — | IC50 | = | 65.6 | nM | 7.18 |
| CHEMBL4867229 | — | IC50 | = | 69.4 | nM | 7.16 |
| CHEMBL4877277 | — | IC50 | = | 184.1 | nM | 6.74 |
| CHEMBL4869559 | — | IC50 | = | 237.7 | nM | 6.62 |
| CHEMBL4866610 | — | IC50 | = | 261.5 | nM | 6.58 |
| CHEMBL451887 | CARFILZOMIB | IC50 | - | — | - |