Assay Detail
Toxicity
CHEMBL5509546
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Cytotoxicity against human HMC3 cells assessed as reduction in cell viability incubated for 96 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HMC3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.21 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 7.80 |
| CHEMBL4100295 | — | — | 1 | 4.62 |
| CHEMBL4866610 | — | — | 1 | - |
| CHEMBL4869559 | — | — | 1 | - |
| CHEMBL4855585 | — | — | 1 | - |
| CHEMBL5555733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4100295 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4866610 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4869559 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4855585 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5555733 | — | IC50 | > | 100000.0 | nM | - |