Assay Detail
Functional
CHEMBL5509697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT2AR expressed in HEK293 cells incubated upto 90 sec by Fluo-4 AM dye based Ca2+ imaging assay
40
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT<sub>2A</sub> Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 6.98 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292821 | — | — | 1 | 8.80 |
| CHEMBL5527952 | — | — | 1 | 8.80 |
| CHEMBL5531940 | — | — | 2 | 8.49 |
| CHEMBL5532283 | — | — | 2 | 8.28 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.14 |
| CHEMBL5532020 | — | — | 2 | 8.00 |
| CHEMBL5555278 | — | — | 2 | 7.58 |
| CHEMBL5558376 | — | — | 2 | 7.43 |
| CHEMBL5517964 | — | — | 2 | 7.42 |
| CHEMBL5557170 | — | — | 2 | 7.42 |
| CHEMBL5558409 | — | — | 2 | 7.39 |
| CHEMBL5557122 | — | — | 2 | 7.18 |
| CHEMBL5560448 | — | — | 1 | 7.16 |
| CHEMBL5517765 | — | — | 2 | 7.16 |
| CHEMBL5555473 | — | — | 2 | 7.00 |
| CHEMBL5556954 | — | — | 2 | 7.00 |
| CHEMBL5565114 | — | — | 1 | 6.82 |
| CHEMBL5517969 | — | — | 2 | 6.80 |
| CHEMBL5537031 | — | — | 2 | 6.57 |
| CHEMBL5556242 | — | — | 2 | 6.57 |
| CHEMBL5537074 | — | — | 1 | 6.41 |
| CHEMBL5523588 | — | — | 1 | 5.96 |
| CHEMBL5542989 | — | — | 1 | 5.82 |
| CHEMBL5556762 | — | — | 2 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292821 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5527952 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5531940 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5531940 | — | EC50 | = | 3.236 | nM | 8.49 |
| CHEMBL5532283 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL39 | SEROTONIN | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5532283 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5532020 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5555278 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5558376 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5557170 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5517964 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5558409 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5557122 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5517765 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5560448 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5555473 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5556954 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5558409 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5565114 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5517969 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5555278 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5517964 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5558376 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5555473 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5537031 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5556242 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5517969 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5532020 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5537031 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5537074 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5557170 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5517765 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5557122 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5523588 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5542989 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5556762 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5556242 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5556762 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5556954 | — | EC50 | = | 3000.0 | nM | 5.52 |