Assay Detail
Functional
CHEMBL5509700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT2CR expressed in HEK293 cells incubated upto 90 sec by Fluo-4 AM dye based Ca2+ imaging assay
23
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT<sub>2A</sub> Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.12 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.58 |
| CHEMBL292821 | — | — | 1 | 5.39 |
| CHEMBL5527952 | — | — | 1 | 5.28 |
| CHEMBL5532283 | — | — | 2 | 4.75 |
| CHEMBL5557122 | — | — | 1 | - |
| CHEMBL5558376 | — | — | 1 | - |
| CHEMBL5556242 | — | — | 1 | - |
| CHEMBL5565114 | — | — | 1 | - |
| CHEMBL5555473 | — | — | 1 | - |
| CHEMBL5558409 | — | — | 2 | - |
| CHEMBL5537031 | — | — | 1 | - |
| CHEMBL5555278 | — | — | 2 | - |
| CHEMBL5517964 | — | — | 2 | - |
| CHEMBL5517969 | — | — | 1 | - |
| CHEMBL5537074 | — | — | 1 | - |
| CHEMBL5517765 | — | — | 1 | - |
| CHEMBL5556762 | — | — | 1 | - |
| CHEMBL5557170 | — | — | 1 | - |
| CHEMBL5532020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL292821 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5527952 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5532283 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5532283 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5557122 | — | EC50 | = | 1800000.0 | nM | - |
| CHEMBL5558376 | — | EC50 | = | 2800000.0 | nM | - |
| CHEMBL5556242 | — | EC50 | ~ | 10000000.0 | nM | - |
| CHEMBL5565114 | — | EC50 | = | 860000.0 | nM | - |
| CHEMBL5555473 | — | EC50 | = | 1200000.0 | nM | - |
| CHEMBL5558409 | — | EC50 | = | 380000.0 | nM | - |
| CHEMBL5558409 | — | EC50 | = | 640000.0 | nM | - |
| CHEMBL5537031 | — | EC50 | = | 1600000.0 | nM | - |
| CHEMBL5555278 | — | EC50 | = | 510000.0 | nM | - |
| CHEMBL5555278 | — | EC50 | = | 2300000.0 | nM | - |
| CHEMBL5517964 | — | EC50 | = | 570000.0 | nM | - |
| CHEMBL5517964 | — | EC50 | = | 780000.0 | nM | - |
| CHEMBL5517969 | — | EC50 | = | 2300000.0 | nM | - |
| CHEMBL5537074 | — | EC50 | = | 920000.0 | nM | - |
| CHEMBL5517765 | — | EC50 | = | 1400000.0 | nM | - |
| CHEMBL5556762 | — | EC50 | = | 1400000.0 | nM | - |
| CHEMBL5557170 | — | EC50 | = | 2700000.0 | nM | - |
| CHEMBL5532020 | — | EC50 | = | 290000.0 | nM | - |