Assay Detail
Functional
CHEMBL5509726
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Antiproliferative activity against human MOLM16 cells incubated for 72 hrs by Cell-Titer Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-16 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong <i>In Vivo</i> Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.73 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562829 | — | — | 1 | 8.34 |
| CHEMBL5542816 | — | — | 1 | 8.26 |
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 7.89 |
| CHEMBL5555598 | — | — | 1 | 7.84 |
| CHEMBL5532556 | — | — | 1 | 7.34 |
| CHEMBL5561968 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562829 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5542816 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4785363 | INOBRODIB | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5555598 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5532556 | — | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL5561968 | — | IC50 | = | 199.5 | nM | 6.70 |