Assay Detail

CHEMBL5509815

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Binding

Binding affinity to CBP (unknown origin) by SPR method

ChEMBL ↗

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Target

CREB-binding protein (CHEMBL5747) ↗

Open DB target context

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CREB-binding protein (CHEMBL5747) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target CREB-binding protein

CHEMBL5747

Anchored from Assay target.

Protein identity CREB-binding protein

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

CREB-binding protein (CHEMBL5747) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong <i>In Vivo</i> Antitumor Activity.

Hu J, Xu H, Wu T, Zhang C, Shen H, Dong R, Hu Q, Xiang Q, Chai S, Luo G, Chen X, Huang Y, Zhao X, Peng C, Wu X, Lin B, Zhang Y, Xu Y.
J Med Chem (2024) 67 : 6952 -6986
PubMed 38649304 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	8.77	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4785363	INOBRODIB	1.0	1	8.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4785363	INOBRODIB	Kd	=	1.7	nM	8.77