Assay Detail
Binding
CHEMBL5509844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT (unknown origin)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.26 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562374 | — | — | 1 | 7.90 |
| CHEMBL5555761 | — | — | 1 | 7.82 |
| CHEMBL5565608 | — | — | 1 | 7.65 |
| CHEMBL5560093 | — | — | 1 | 7.61 |
| CHEMBL5558561 | — | — | 1 | 7.61 |
| CHEMBL5568314 | — | — | 1 | 7.61 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.59 |
| CHEMBL5557130 | — | — | 1 | 7.59 |
| CHEMBL5562168 | — | — | 1 | 7.49 |
| CHEMBL5532628 | — | — | 1 | 7.49 |
| CHEMBL5517720 | — | — | 1 | 7.48 |
| CHEMBL5562661 | — | — | 1 | 7.42 |
| CHEMBL5556411 | — | — | 1 | 7.40 |
| CHEMBL5560983 | — | — | 1 | 7.38 |
| CHEMBL5558278 | — | — | 1 | 7.37 |
| CHEMBL5562131 | — | — | 1 | 7.34 |
| CHEMBL5562174 | — | — | 1 | 7.31 |
| CHEMBL5564653 | — | — | 1 | 7.29 |
| CHEMBL5556636 | — | — | 1 | 7.27 |
| CHEMBL5559189 | — | — | 1 | 7.27 |
| CHEMBL5542491 | — | — | 1 | 7.24 |
| CHEMBL5563161 | — | — | 1 | 7.18 |
| CHEMBL5557787 | — | — | 1 | 7.09 |
| CHEMBL5556923 | — | — | 1 | 6.96 |
| CHEMBL5518080 | — | — | 1 | 6.90 |
| CHEMBL5561682 | — | — | 1 | 6.79 |
| CHEMBL5523524 | — | — | 1 | 6.71 |
| CHEMBL5557008 | — | — | 1 | 6.66 |
| CHEMBL5517910 | — | — | 1 | 6.62 |
| CHEMBL5567202 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562374 | — | IC50 | = | 12.56 | nM | 7.90 |
| CHEMBL5555761 | — | IC50 | = | 15.07 | nM | 7.82 |
| CHEMBL5565608 | — | IC50 | = | 22.43 | nM | 7.65 |
| CHEMBL5560093 | — | IC50 | = | 24.31 | nM | 7.61 |
| CHEMBL5558561 | — | IC50 | = | 24.79 | nM | 7.61 |
| CHEMBL5568314 | — | IC50 | = | 24.37 | nM | 7.61 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL5557130 | — | IC50 | = | 25.46 | nM | 7.59 |
| CHEMBL5562168 | — | IC50 | = | 32.17 | nM | 7.49 |
| CHEMBL5532628 | — | IC50 | = | 32.56 | nM | 7.49 |
| CHEMBL5517720 | — | IC50 | = | 33.15 | nM | 7.48 |
| CHEMBL5562661 | — | IC50 | = | 37.98 | nM | 7.42 |
| CHEMBL5556411 | — | IC50 | = | 39.79 | nM | 7.40 |
| CHEMBL5560983 | — | IC50 | = | 42.17 | nM | 7.38 |
| CHEMBL5558278 | — | IC50 | = | 42.51 | nM | 7.37 |
| CHEMBL5562131 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL5562174 | — | IC50 | = | 49.21 | nM | 7.31 |
| CHEMBL5564653 | — | IC50 | = | 51.43 | nM | 7.29 |
| CHEMBL5556636 | — | IC50 | = | 54.1 | nM | 7.27 |
| CHEMBL5559189 | — | IC50 | = | 53.17 | nM | 7.27 |
| CHEMBL5542491 | — | IC50 | = | 58.13 | nM | 7.24 |
| CHEMBL5563161 | — | IC50 | = | 65.43 | nM | 7.18 |
| CHEMBL5557787 | — | IC50 | = | 81.2 | nM | 7.09 |
| CHEMBL5556923 | — | IC50 | = | 109.3 | nM | 6.96 |
| CHEMBL5518080 | — | IC50 | = | 127.2 | nM | 6.90 |
| CHEMBL5561682 | — | IC50 | = | 161.8 | nM | 6.79 |
| CHEMBL5523524 | — | IC50 | = | 193.4 | nM | 6.71 |
| CHEMBL5557008 | — | IC50 | = | 221.2 | nM | 6.66 |
| CHEMBL5517910 | — | IC50 | = | 241.4 | nM | 6.62 |
| CHEMBL5567202 | — | IC50 | = | 279.3 | nM | 6.55 |
| CHEMBL5556209 | — | IC50 | = | 373.6 | nM | 6.43 |