Assay Detail
Functional
CHEMBL5510097
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Antiproliferative activity against human MV4-11 cells incubated for 5 days by CellTiter-Glo luminescent cell viability assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.93 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561973 | — | — | 1 | 8.24 |
| CHEMBL5532008 | — | — | 1 | 7.49 |
| CHEMBL5555428 | — | — | 1 | 7.47 |
| CHEMBL5559097 | — | — | 1 | 7.41 |
| CHEMBL4225966 | SEL-120 FREE BASE | 1.0 | 1 | 7.36 |
| CHEMBL5562755 | — | — | 1 | 7.14 |
| CHEMBL5543020 | — | — | 1 | 6.83 |
| CHEMBL5560894 | — | — | 1 | 6.82 |
| CHEMBL5557301 | — | — | 1 | 6.73 |
| CHEMBL5559293 | — | — | 1 | 6.44 |
| CHEMBL5550075 | — | — | 1 | 6.38 |
| CHEMBL5512552 | — | — | 1 | 6.32 |
| CHEMBL5523465 | — | — | 1 | 6.28 |
| CHEMBL5561332 | — | — | 1 | 6.10 |
| CHEMBL5561031 | — | — | 1 | - |
| CHEMBL5523566 | — | — | 1 | - |
| CHEMBL5542174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561973 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5532008 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL5555428 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL5559097 | — | IC50 | = | 39.4 | nM | 7.41 |
| CHEMBL4225966 | SEL-120 FREE BASE | IC50 | = | 43.77 | nM | 7.36 |
| CHEMBL5562755 | — | IC50 | = | 72.5 | nM | 7.14 |
| CHEMBL5543020 | — | IC50 | = | 146.2 | nM | 6.83 |
| CHEMBL5560894 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5557301 | — | IC50 | = | 187.6 | nM | 6.73 |
| CHEMBL5559293 | — | IC50 | = | 360.4 | nM | 6.44 |
| CHEMBL5550075 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL5512552 | — | IC50 | = | 477.9 | nM | 6.32 |
| CHEMBL5523465 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL5561332 | — | IC50 | = | 794.7 | nM | 6.10 |
| CHEMBL5561031 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5523566 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5542174 | — | IC50 | > | 1000.0 | nM | - |