Assay Detail
Binding
CHEMBL5510135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CLK2 (unknown origin) by ADP-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.76 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561973 | — | — | 1 | 7.84 |
| CHEMBL4225966 | SEL-120 FREE BASE | 1.0 | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561973 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4225966 | SEL-120 FREE BASE | IC50 | = | 21.0 | nM | 7.68 |