Assay Detail

CHEMBL5510398

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Functional

Antiproliferative activity against FGF19 amplified human JHH7 cells assessed as inhibition of cell growth by SRB assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	JHH7
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of 2,6-Naphthyridine Analogues as Selective FGFR4 Inhibitors for Hepatocellular Carcinoma.

Oh H, Kim J, Jung SH, Ha TH, Ahn YG, Nam G, Moon K, Singh P, Kim IS.
J Med Chem (2024) 67 : 8445 -8459
PubMed 38706130 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.14	7.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5567997	—	—	1	7.48
CHEMBL4514636	FISOGATINIB	2.0	1	6.79

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5567997	—	IC50	=	33.0	nM	7.48
CHEMBL4514636	FISOGATINIB	IC50	=	161.0	nM	6.79