Assay Detail
Binding
CHEMBL5510484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant GCPIII assessed as dissociation constant by fluorescence polarization assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N-acetylated-alpha-linked acidic dipeptidase 2 (CHEMBL2609) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Glutamate Carboxypeptidase III Ligands to Compete the Uptake of [<sup>177</sup>Lu]Lu-PSMA-617 in Healthy Organs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 24 | 7.85 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560474 | — | — | 1 | 8.77 |
| CHEMBL5557579 | — | — | 1 | 8.37 |
| CHEMBL5565532 | — | — | 1 | 8.35 |
| CHEMBL5561626 | — | — | 1 | 8.32 |
| CHEMBL5561704 | — | — | 1 | 8.20 |
| CHEMBL5561251 | — | — | 1 | 8.19 |
| CHEMBL5558611 | — | — | 1 | 8.15 |
| CHEMBL5557217 | — | — | 1 | 7.92 |
| CHEMBL5557349 | — | — | 1 | 7.85 |
| CHEMBL5555029 | — | — | 1 | 7.82 |
| CHEMBL5556760 | — | — | 1 | 7.64 |
| CHEMBL5558512 | — | — | 1 | 7.62 |
| CHEMBL5555028 | — | — | 1 | 7.52 |
| CHEMBL5561889 | — | — | 1 | 7.06 |
| CHEMBL5532072 | — | — | 1 | 6.97 |
| CHEMBL5562614 | — | — | 1 | 6.77 |
| CHEMBL5562592 | — | — | 1 | - |
| CHEMBL5560002 | — | — | 1 | - |
| CHEMBL5542221 | — | — | 1 | - |
| CHEMBL5518058 | — | — | 1 | - |
| CHEMBL5565084 | — | — | 1 | - |
| CHEMBL5556963 | — | — | 1 | - |
| CHEMBL5555147 | — | — | 1 | - |
| CHEMBL5566819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560474 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL5557579 | — | Kd | = | 4.3 | nM | 8.37 |
| CHEMBL5565532 | — | Kd | = | 4.5 | nM | 8.35 |
| CHEMBL5561626 | — | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL5561704 | — | Kd | = | 6.3 | nM | 8.20 |
| CHEMBL5561251 | — | Kd | = | 6.4 | nM | 8.19 |
| CHEMBL5558611 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL5557217 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL5557349 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL5555029 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL5556760 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL5558512 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL5555028 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL5561889 | — | Kd | = | 87.0 | nM | 7.06 |
| CHEMBL5532072 | — | Kd | = | 106.0 | nM | 6.97 |
| CHEMBL5562614 | — | Kd | = | 169.0 | nM | 6.77 |
| CHEMBL5562592 | — | Kd | > | 500.0 | nM | - |
| CHEMBL5560002 | — | Kd | > | 500.0 | nM | - |
| CHEMBL5542221 | — | Kd | > | 500.0 | nM | - |
| CHEMBL5518058 | — | Kd | > | 300.0 | nM | - |
| CHEMBL5565084 | — | Kd | > | 300.0 | nM | - |
| CHEMBL5556963 | — | Kd | > | 300.0 | nM | - |
| CHEMBL5555147 | — | Kd | > | 500.0 | nM | - |
| CHEMBL5566819 | — | Kd | > | 2600.0 | nM | - |