Assay Detail
Binding
CHEMBL5510885
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PAD2 (unknown origin) using Nalpha-benzoyl-L-arginine ethyl ester as substrate preincubated for 60 mins followed by substrate addition and measured after 90 mins by colorimetric analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-arginine deiminase type-2 (CHEMBL1909487) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.60 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5542325 | — | — | 1 | 6.46 |
| CHEMBL5532370 | — | — | 1 | 6.08 |
| CHEMBL5562134 | — | — | 1 | 6.00 |
| CHEMBL5555170 | — | — | 1 | 5.99 |
| CHEMBL5563751 | — | — | 1 | 5.94 |
| CHEMBL5564382 | — | — | 1 | 5.90 |
| CHEMBL5564422 | — | — | 1 | 5.88 |
| CHEMBL5560601 | — | — | 1 | 5.87 |
| CHEMBL5559926 | — | — | 1 | 5.84 |
| CHEMBL5527968 | — | — | 1 | 5.82 |
| CHEMBL5556269 | — | — | 1 | 5.79 |
| CHEMBL5562016 | — | — | 1 | 5.71 |
| CHEMBL5559509 | — | — | 1 | 5.68 |
| CHEMBL5565461 | — | — | 1 | 5.68 |
| CHEMBL5560885 | — | — | 1 | 5.65 |
| CHEMBL5563821 | — | — | 1 | 5.64 |
| CHEMBL5562945 | — | — | 1 | 5.63 |
| CHEMBL5555615 | — | — | 1 | 5.56 |
| CHEMBL5558736 | — | — | 1 | 5.53 |
| CHEMBL5562648 | — | — | 1 | 5.53 |
| CHEMBL5542302 | — | — | 1 | 5.52 |
| CHEMBL5556573 | — | — | 1 | 5.52 |
| CHEMBL5560217 | — | — | 1 | 5.44 |
| CHEMBL5567700 | — | — | 1 | 5.42 |
| CHEMBL5555765 | — | — | 1 | 5.39 |
| CHEMBL5563295 | — | — | 1 | 5.37 |
| CHEMBL5564029 | — | — | 1 | 5.34 |
| CHEMBL5561457 | — | — | 1 | 5.33 |
| CHEMBL3682418 | — | — | 1 | 5.28 |
| CHEMBL5566624 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5542325 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5532370 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5562134 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5555170 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5563751 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5564382 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5564422 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5560601 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5559926 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5527968 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL5556269 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5562016 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL5559509 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5565461 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5560885 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5563821 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL5562945 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL5555615 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5558736 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5562648 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5556573 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL5542302 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5560217 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5567700 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL5555765 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL5563295 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL5564029 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL5561457 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL3682418 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL5566624 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5564618 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5568119 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5518030 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL5560100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555673 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5558439 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555892 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5568266 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5560309 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5560638 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5517956 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5559918 | — | IC50 | > | 10000.0 | nM | - |