Assay Detail
Toxicity
CHEMBL5510889
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.01 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562945 | — | — | 1 | 5.56 |
| CHEMBL5560309 | — | — | 1 | 5.56 |
| CHEMBL5517956 | — | — | 1 | 5.52 |
| CHEMBL5568266 | — | — | 1 | 5.52 |
| CHEMBL5563295 | — | — | 1 | 5.51 |
| CHEMBL5558439 | — | — | 1 | 5.45 |
| CHEMBL5560601 | — | — | 1 | 5.42 |
| CHEMBL5560638 | — | — | 1 | 5.40 |
| CHEMBL5563751 | — | — | 1 | 5.39 |
| CHEMBL3682418 | — | — | 1 | 5.37 |
| CHEMBL5564382 | — | — | 1 | 5.36 |
| CHEMBL5555170 | — | — | 1 | 5.29 |
| CHEMBL5559918 | — | — | 1 | 5.28 |
| CHEMBL5555765 | — | — | 1 | 5.20 |
| CHEMBL5556573 | — | — | 1 | 5.20 |
| CHEMBL5558736 | — | — | 1 | 5.15 |
| CHEMBL5560100 | — | — | 1 | 5.14 |
| CHEMBL5560217 | — | — | 1 | 5.10 |
| CHEMBL5567700 | — | — | 1 | 5.09 |
| CHEMBL5562648 | — | — | 1 | 5.08 |
| CHEMBL5555892 | — | — | 1 | 5.01 |
| CHEMBL5564029 | — | — | 1 | 4.96 |
| CHEMBL5562134 | — | — | 1 | 4.96 |
| CHEMBL5542302 | — | — | 1 | 4.96 |
| CHEMBL5564618 | — | — | 1 | 4.91 |
| CHEMBL5518030 | — | — | 1 | 4.84 |
| CHEMBL5527968 | — | — | 1 | 4.83 |
| CHEMBL5556269 | — | — | 1 | 4.77 |
| CHEMBL5555673 | — | — | 1 | 4.76 |
| CHEMBL5532370 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562945 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL5560309 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL5517956 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5568266 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL5563295 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL5558439 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5560601 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5560638 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL5563751 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL3682418 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5564382 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5555170 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL5559918 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5555765 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL5556573 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL5558736 | — | IC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL5560100 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL5560217 | — | IC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL5567700 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL5562648 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL5555892 | — | IC50 | = | 9730.0 | nM | 5.01 |
| CHEMBL5564029 | — | IC50 | = | 11060.0 | nM | 4.96 |
| CHEMBL5542302 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5562134 | — | IC50 | = | 10970.0 | nM | 4.96 |
| CHEMBL5564618 | — | IC50 | = | 12410.0 | nM | 4.91 |
| CHEMBL5518030 | — | IC50 | = | 14320.0 | nM | 4.84 |
| CHEMBL5527968 | — | IC50 | = | 14660.0 | nM | 4.83 |
| CHEMBL5556269 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL5555673 | — | IC50 | = | 17460.0 | nM | 4.76 |
| CHEMBL5532370 | — | IC50 | = | 18220.0 | nM | 4.74 |
| CHEMBL5566624 | — | IC50 | = | 29660.0 | nM | 4.53 |
| CHEMBL5555615 | — | IC50 | = | 29360.0 | nM | 4.53 |
| CHEMBL5560885 | — | IC50 | = | 51790.0 | nM | 4.29 |
| CHEMBL5563821 | — | IC50 | = | 54030.0 | nM | 4.27 |
| CHEMBL5559926 | — | IC50 | = | 63640.0 | nM | 4.20 |
| CHEMBL5559509 | — | IC50 | = | 72670.0 | nM | 4.14 |
| CHEMBL5561457 | — | IC50 | = | 83810.0 | nM | 4.08 |
| CHEMBL5542325 | — | IC50 | = | 120430.0 | nM | - |
| CHEMBL5565461 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5562016 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5568119 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5564422 | — | IC50 | > | 100000.0 | nM | - |