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Assay Detail

CHEMBL5511081

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human GL261 cells incubated for 72 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type GL261
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy.
Yang Z, Liu Z, Wan S, Xu J, Huang Y, He H, Liu T, Li L, Ren Y, Zhang J, Chen J.
J Med Chem (2024) 67 : 7995 -8019
PubMed 38739112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.52 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5559947 1 5.92
CHEMBL5556281 1 5.91
CHEMBL5564226 1 5.75
CHEMBL5558740 1 5.71
CHEMBL5555620 1 5.67
CHEMBL5517715 1 5.65
CHEMBL5523403 1 5.65
CHEMBL5560649 1 5.62
CHEMBL5560076 1 5.58
CHEMBL5558842 1 5.57
CHEMBL5562753 1 5.56
CHEMBL5558630 1 5.49
CHEMBL5562495 1 5.49
CHEMBL5523580 1 5.48
CHEMBL5565051 1 5.26
CHEMBL4089730 1 5.24
CHEMBL5559858 1 5.16
CHEMBL939 GEFITINIB 4.0 1 4.67
CHEMBL5556352 1 -
CHEMBL5561232 1 -
CHEMBL5557155 1 -
CHEMBL5537075 1 -
CHEMBL5532015 1 -
CHEMBL5558514 1 -
CHEMBL5555786 1 -
CHEMBL5566977 1 -
CHEMBL5556032 1 -
CHEMBL4639202 1 -
CHEMBL5562572 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5559947 IC50 = 1190.0 nM 5.92
CHEMBL5556281 IC50 = 1240.0 nM 5.91
CHEMBL5564226 IC50 = 1790.0 nM 5.75
CHEMBL5558740 IC50 = 1970.0 nM 5.71
CHEMBL5555620 IC50 = 2160.0 nM 5.67
CHEMBL5517715 IC50 = 2250.0 nM 5.65
CHEMBL5523403 IC50 = 2240.0 nM 5.65
CHEMBL5560649 IC50 = 2390.0 nM 5.62
CHEMBL5560076 IC50 = 2630.0 nM 5.58
CHEMBL5558842 IC50 = 2720.0 nM 5.57
CHEMBL5562753 IC50 = 2760.0 nM 5.56
CHEMBL5558630 IC50 = 3220.0 nM 5.49
CHEMBL5562495 IC50 = 3250.0 nM 5.49
CHEMBL5523580 IC50 = 3300.0 nM 5.48
CHEMBL5565051 IC50 = 5460.0 nM 5.26
CHEMBL4089730 IC50 = 5720.0 nM 5.24
CHEMBL5559858 IC50 = 6860.0 nM 5.16
CHEMBL939 GEFITINIB IC50 = 21540.0 nM 4.67
CHEMBL5556352 IC50 > 20000.0 nM -
CHEMBL5561232 IC50 > 20000.0 nM -
CHEMBL5557155 IC50 > 20000.0 nM -
CHEMBL5537075 IC50 > 20000.0 nM -
CHEMBL5532015 IC50 > 20000.0 nM -
CHEMBL5558514 IC50 > 20000.0 nM -
CHEMBL5555786 IC50 > 20000.0 nM -
CHEMBL5566977 IC50 > 20000.0 nM -
CHEMBL5556032 IC50 > 20000.0 nM -
CHEMBL4639202 IC50 > 20000.0 nM -
CHEMBL5562572 IC50 > 20000.0 nM -