Assay Detail
Binding
CHEMBL5511306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at human alpha9 nAChR expressed as xenopus laevis oocytes assessed as increase in receptor desensitization measured after 120 secs by two-electrode voltage-clamp electrophysiology method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-9 (CHEMBL2184) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.15 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561901 | — | — | 1 | 5.95 |
| CHEMBL5557858 | — | — | 1 | 5.16 |
| CHEMBL5542521 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561901 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5557858 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5542521 | — | EC50 | = | 45000.0 | nM | 4.35 |