Assay Detail
Functional
CHEMBL5511331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATP-mediated IL-1beta release in LPS primed BzATP induced monocytic human THP-1 cells primed with LPS for 5 hrs followed by BzATP and compound addition for 40 mins by ELISA
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.40 | 6.30 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558610 | — | — | 2 | 6.30 |
| CHEMBL5555218 | — | — | 2 | 5.05 |
| CHEMBL5556786 | — | — | 2 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558610 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5555218 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5556786 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5556786 | — | Inhibition | - | % | - | |
| CHEMBL5555218 | — | Inhibition | - | % | - | |
| CHEMBL5558610 | — | Inhibition | - | % | - |