Assay Detail
Binding
CHEMBL5511452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to NLRP3 (unknown origin) expressed in HEK293T cells incubated for 30 mins by MST assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL1741208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.63 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183703 | — | — | 1 | 9.27 |
| CHEMBL5567870 | — | — | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183703 | — | Kd | = | 0.532 | nM | 9.27 |
| CHEMBL5567870 | — | Kd | = | 10.55 | nM | 7.98 |