Assay Detail
Binding
CHEMBL5511933
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Inhibition of recombinant human CD73 expressed in Escherichia coli using AMP as substrate measured after 60 mins by malachite green method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Novel Non-Nucleoside Inhibitors Interacting with Dizinc Ions of CD73.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471306 | QUEMLICLUSTAT | 2.0 | 1 | 9.00 |
| CHEMBL5557596 | — | — | 1 | 7.22 |
| CHEMBL5566148 | — | — | 1 | 6.89 |
| CHEMBL4792487 | LY-3475070 | 1.0 | 1 | 6.77 |
| CHEMBL5568463 | — | — | 1 | 6.72 |
| CHEMBL5564189 | — | — | 1 | 6.70 |
| CHEMBL5556485 | — | — | 1 | 6.70 |
| CHEMBL5563978 | — | — | 1 | 6.48 |
| CHEMBL5557723 | — | — | 1 | 6.43 |
| CHEMBL5532247 | — | — | 1 | 6.31 |
| CHEMBL5560132 | — | — | 1 | 6.28 |
| CHEMBL5523448 | — | — | 1 | 6.27 |
| CHEMBL5556213 | — | — | 1 | 6.23 |
| CHEMBL5556250 | — | — | 1 | 6.16 |
| CHEMBL5559598 | — | — | 1 | 6.16 |
| CHEMBL5512523 | — | — | 1 | 6.11 |
| CHEMBL5568218 | — | — | 1 | 6.05 |
| CHEMBL5557348 | — | — | 1 | 6.05 |
| CHEMBL4576728 | — | — | 1 | 6.02 |
| CHEMBL5532200 | — | — | 1 | 5.99 |
| CHEMBL5559767 | — | — | 1 | 5.96 |
| CHEMBL5561267 | — | — | 1 | 5.88 |
| CHEMBL5556305 | — | — | 1 | 5.85 |
| CHEMBL5537034 | — | — | 1 | 5.84 |
| CHEMBL5527834 | — | — | 1 | 5.81 |
| CHEMBL5561805 | — | — | 1 | 5.68 |
| CHEMBL5559802 | — | — | 1 | 5.06 |
| CHEMBL5566507 | — | — | 1 | 4.46 |
| CHEMBL5560107 | — | — | 1 | - |
| CHEMBL5532612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471306 | QUEMLICLUSTAT | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5557596 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5566148 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4792487 | LY-3475070 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5568463 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5564189 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5556485 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5563978 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5557723 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5532247 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5560132 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5523448 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5556213 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5556250 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5559598 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5512523 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5568218 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5557348 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4576728 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5532200 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5559767 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5561267 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5556305 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL5537034 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5527834 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5561805 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL5559802 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5566507 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5560107 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5532612 | — | IC50 | > | 20000.0 | nM | - |