Assay Detail
Binding
CHEMBL5511956
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 hrs by NanoBRET assay
109
Total Activities
109
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor (CHEMBL3108660) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 109 | 5.54 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5531987 | — | — | 1 | 8.48 |
| CHEMBL5568405 | — | — | 1 | 8.20 |
| CHEMBL5561098 | — | — | 1 | 7.23 |
| CHEMBL5557410 | — | — | 1 | 7.20 |
| CHEMBL5523602 | — | — | 1 | 7.17 |
| CHEMBL5565598 | — | — | 1 | 7.13 |
| CHEMBL5557627 | — | — | 1 | 7.07 |
| CHEMBL5532286 | — | — | 1 | 7.07 |
| CHEMBL5567564 | — | — | 1 | 7.00 |
| CHEMBL5556367 | — | — | 1 | 6.96 |
| CHEMBL5523400 | — | — | 1 | 6.89 |
| CHEMBL5559950 | — | — | 1 | 6.89 |
| CHEMBL5550038 | — | — | 1 | 6.80 |
| CHEMBL4565531 | — | — | 1 | 6.75 |
| CHEMBL3344081 | — | — | 1 | 6.70 |
| CHEMBL5566779 | — | — | 1 | 6.58 |
| CHEMBL5567920 | — | — | 1 | 6.58 |
| CHEMBL5560777 | — | — | 1 | 6.17 |
| CHEMBL5562051 | — | — | 1 | 5.89 |
| CHEMBL5562118 | — | — | 1 | 5.72 |
| CHEMBL5561983 | — | — | 1 | 5.70 |
| CHEMBL5563285 | — | — | 1 | 5.70 |
| CHEMBL5558694 | — | — | 1 | 5.62 |
| CHEMBL5542362 | — | — | 1 | 5.60 |
| CHEMBL5555944 | — | — | 1 | 5.52 |
| CHEMBL5562734 | — | — | 1 | 5.47 |
| CHEMBL5560099 | — | — | 1 | 5.40 |
| CHEMBL5556974 | — | — | 1 | 5.36 |
| CHEMBL5532505 | — | — | 1 | 5.34 |
| CHEMBL5565425 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5531987 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL5568405 | — | Kd | = | 6.3 | nM | 8.20 |
| CHEMBL5561098 | — | Kd | = | 59.0 | nM | 7.23 |
| CHEMBL5557410 | — | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL5523602 | — | Kd | = | 67.0 | nM | 7.17 |
| CHEMBL5565598 | — | Kd | = | 74.0 | nM | 7.13 |
| CHEMBL5532286 | — | Kd | = | 85.0 | nM | 7.07 |
| CHEMBL5557627 | — | Kd | = | 85.0 | nM | 7.07 |
| CHEMBL5567564 | — | Kd | = | 99.0 | nM | 7.00 |
| CHEMBL5556367 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL5559950 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL5523400 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL5550038 | — | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL4565531 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL3344081 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL5567920 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL5566779 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL5560777 | — | Kd | = | 680.0 | nM | 6.17 |
| CHEMBL5562051 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL5562118 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL5561983 | — | Kd | = | 1990.0 | nM | 5.70 |
| CHEMBL5563285 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL5558694 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL5542362 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL5555944 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL5562734 | — | Kd | = | 3370.0 | nM | 5.47 |
| CHEMBL5560099 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL5556974 | — | Kd | = | 4400.0 | nM | 5.36 |
| CHEMBL5532505 | — | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL5565425 | — | Kd | = | 5170.0 | nM | 5.29 |
| CHEMBL5559916 | — | Kd | = | 5500.0 | nM | 5.26 |
| CHEMBL5560147 | — | Kd | = | 6100.0 | nM | 5.21 |
| CHEMBL5527840 | — | Kd | = | 6600.0 | nM | 5.18 |
| CHEMBL5517736 | — | Kd | = | 6600.0 | nM | 5.18 |
| CHEMBL5523429 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL5518083 | — | Kd | = | 7400.0 | nM | 5.13 |
| CHEMBL5517933 | — | Kd | = | 7700.0 | nM | 5.11 |
| CHEMBL5556945 | — | Kd | = | 7700.0 | nM | 5.11 |
| CHEMBL5567365 | — | Kd | = | 8700.0 | nM | 5.06 |
| CHEMBL5542093 | — | Kd | = | 9200.0 | nM | 5.04 |
| CHEMBL5532172 | — | Kd | = | 9700.0 | nM | 5.01 |
| CHEMBL5560333 | — | Kd | = | 10300.0 | nM | 4.99 |
| CHEMBL5556018 | — | Kd | = | 10500.0 | nM | 4.98 |
| CHEMBL5565978 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL5566856 | — | Kd | = | 11800.0 | nM | 4.93 |
| CHEMBL5562466 | — | Kd | = | 12200.0 | nM | 4.91 |
| CHEMBL5517989 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL5558821 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL5560621 | — | Kd | = | 15400.0 | nM | 4.81 |
| CHEMBL5560816 | — | Kd | = | 17800.0 | nM | 4.75 |