Assay Detail
Functional
CHEMBL5511977
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Partial agonist activity at human DOR expressed in CHO-K1 cells assessed as decrease in cAMP level incubated for 30 mins in presence of forskolin by HitHunter cAMP analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.83 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511142 | BUPRENORPHINE | 4.0 | 1 | 9.07 |
| CHEMBL5568344 | — | — | 1 | 8.75 |
| CHEMBL5523416 | — | — | 1 | 8.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511142 | BUPRENORPHINE | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5568344 | — | EC50 | = | 1.77 | nM | 8.75 |
| CHEMBL5523416 | — | EC50 | = | 2.18 | nM | 8.66 |