Assay Detail
Functional
CHEMBL5512704
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Antimalarial activity against Plasmodium falciparum 3D7 at asexual stage infected in erythrocytes assessed as parasite growth inhibition incubated for 72 hrs by MSF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triazole hybrid compounds: A new frontier in malaria treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.46 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.24 |
| CHEMBL5272909 | — | — | 1 | 7.41 |
| CHEMBL5274287 | — | — | 1 | 7.40 |
| CHEMBL4777661 | — | — | 1 | 7.40 |
| CHEMBL5275652 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5272909 | — | IC50 | = | 38.75 | nM | 7.41 |
| CHEMBL5274287 | — | IC50 | = | 39.98 | nM | 7.40 |
| CHEMBL4777661 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5275652 | — | IC50 | = | 137.1 | nM | 6.86 |