Assay Detail
Functional
CHEMBL5512965
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Antiproliferative activity against human DiFi cells assessed as inhibition of tumor cell proliferation measured after 8 days by coulter counter method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DiFi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Unlocking the synthetic approaches and clinical application of approved small-molecule drugs for gastrointestinal cancer treatment: A comprehensive exploration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.35 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079742 | ERLOTINIB HYDROCHLORIDE | 4.0 | 1 | 7.70 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079742 | ERLOTINIB HYDROCHLORIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 100.0 | nM | 7.00 |