Assay Detail
Functional
CHEMBL5512993
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells at 0.1 MOI assessed as inhibition of virus induced cytopathic effect by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Development of de-novo coronavirus 3-chymotrypsin-like protease (3CL<sup>pro</sup>) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.09 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560375 | — | — | 1 | 6.43 |
| CHEMBL5562461 | — | — | 1 | 6.27 |
| CHEMBL5555618 | — | — | 1 | 6.07 |
| CHEMBL5532217 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560375 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5562461 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5555618 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5532217 | — | EC50 | = | 2560.0 | nM | 5.59 |