Assay Detail

CHEMBL5513252

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Binding

Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assay

ChEMBL ↗

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Target

Aurora kinase A (CHEMBL4722) ↗

Open DB target context

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Aurora kinase A (CHEMBL4722) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Aurora kinase A

CHEMBL4722

Anchored from Assay target.

Protein identity Aurora kinase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Aurora kinase A (CHEMBL4722) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Therapeutic potential of targeting polo-like kinase 4.

Lei Q, Yu Q, Yang N, Xiao Z, Song C, Zhang R, Yang S, Liu Z, Deng H.
Eur J Med Chem (2024) 265 : 116115 -116115
PubMed 38199166 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.22	9.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL572878	TOZASERTIB	2.0	1	9.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL572878	TOZASERTIB	IC50	=	0.6	nM	9.22