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Assay Detail

CHEMBL5513296

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Drug discovery and optimization based on the co-crystal structure of natural product with target.
Chen X, Varghese S, Zhang Z, Du J, Ruan B, Baell JB, Liu X.
Eur J Med Chem (2024) 266 : 116126 -116126
PubMed 38232464 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.25 8.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5555593 1 8.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5555593 IC50 = 5.6 nM 8.25