Assay Detail
Binding
CHEMBL5513497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of V-ATPase activity in lysosomes of human PC-3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting autophagy drug discovery: Targets, indications and development trends.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 10.14 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 10.52 |
| CHEMBL290814 | BAFILOMYCIN A1 | — | 1 | 10.22 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 9.68 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL290814 | BAFILOMYCIN A1 | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL19612 | SPERMIDINE | IC50 | = | 112000.0 | nM | - |