Assay Detail
Functional
CHEMBL5513506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Downregulation of BNIP3 expression in human HK-2 cells incubated for 6 hrs by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HK-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting autophagy drug discovery: Targets, indications and development trends.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.35 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170596 | — | — | 1 | 8.70 |
| CHEMBL2338329 | ROXADUSTAT | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170596 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2338329 | ROXADUSTAT | IC50 | = | 10.0 | nM | 8.00 |