Assay Detail
Functional
CHEMBL5513588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against influenza A virus A/Udorn/72 (H3N2) harboring wild type M2 ion channel infected in MDCK cells assessed as reduction in plaque formation pre-infected with virus for 2 hrs followed by compound addition and measured after 2 days by crystal violet staining based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tackling Influenza A virus by M2 ion channel blockers: Latest progress and limitations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.29 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561965 | — | — | 1 | 7.16 |
| CHEMBL3770480 | — | — | 1 | 6.52 |
| CHEMBL5556143 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561965 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3770480 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5556143 | — | EC50 | = | 6400.0 | nM | 5.19 |