Assay Detail
Functional
CHEMBL5514031
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Antiproliferative activity against human MKN-1 cells assessed as reduction in cell viability measured for 48 hrs by CCK-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Current advances and development strategies of targeting son of sevenless 1 (SOS1) in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.84 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5209371 | — | — | 1 | 7.58 |
| CHEMBL5192659 | MRTX-0902 | 1.0 | 1 | 7.54 |
| CHEMBL5208088 | — | — | 1 | 7.34 |
| CHEMBL5179610 | — | — | 1 | 7.24 |
| CHEMBL5171096 | — | — | 1 | 6.71 |
| CHEMBL5202863 | — | — | 1 | 6.42 |
| CHEMBL5169564 | — | — | 1 | 6.02 |
| CHEMBL5207802 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5209371 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5192659 | MRTX-0902 | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5208088 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5179610 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5171096 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL5202863 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL5169564 | — | IC50 | = | 958.0 | nM | 6.02 |
| CHEMBL5207802 | — | IC50 | = | 1274.0 | nM | 5.89 |