Assay Detail
Binding
CHEMBL5514045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.29 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 9.10 |
| CHEMBL1241674 | — | — | 1 | 8.10 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1241674 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 20.7 | nM | 7.68 |