Assay Detail
Binding
CHEMBL5514462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length N-terminal His-tagged human PKL (2 to 543 residues) expressed in Escherichia coli by kinase Glo luminescence based plate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfone-based human liver pyruvate kinase inhibitors - Design, synthesis and in vitro bioactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.15 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6338 | — | — | 1 | 7.55 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 7.50 |
| CHEMBL5556210 | — | — | 1 | 7.16 |
| CHEMBL4754666 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6338 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5556210 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4754666 | — | IC50 | = | 410.0 | nM | 6.39 |