Assay Detail
Functional
CHEMBL5514817
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication pretreated with compound for 2 hr followed by viral infection and measured after 48 hrs by indirect immunofluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure-based discovery of potent myosin inhibitors to guide antiparasite drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201746 | PRALATREXATE | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201746 | PRALATREXATE | EC50 | = | 8.0 | nM | 8.10 |