Assay Detail
Binding
CHEMBL5514838
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Displacement of [125I]-1-DMe-NPFF from human NPFF1 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Guanidine-to-piperidine switch affords high affinity small molecule NPFF ligands with preference for NPFF1-R and NPFF2-R subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.51 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4797394 | — | — | 1 | 8.57 |
| CHEMBL4790994 | — | — | 1 | 7.08 |
| CHEMBL5567081 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4797394 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4790994 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL5567081 | — | Ki | = | 136.0 | nM | 6.87 |